Opportunity Information: Apply for PAR 20 238
The National Institutes of Health (NIH) funding opportunity titled "Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)" (PAR-20-238) supports research projects aimed at improving health outcomes in Native American populations, including Alaska Natives and American Indians. The central focus is on developing, adapting, testing, and ultimately helping communities sustain interventions that can reduce illness and prevent early death. The opportunity is designed around the reality that many Native communities face major acute and chronic disease inequities, and that these inequities are often shaped by distinct sociopolitical, historical, environmental, and structural stressors. At the same time, the FOA emphasizes that Native communities also have strengths, resources, and resilience that can and should guide effective, culturally grounded solutions.
The FOA supports several types of intervention-related research along a continuum, depending on what is already known in a given health area. First, it encourages etiologic research when there is a clear and significant gap in knowledge and filling that gap would directly inform how an intervention should be developed or adapted. Second, it funds studies that develop, tailor, or test health promotion and disease prevention interventions, including projects that assess efficacy (whether the intervention works under more controlled conditions) and effectiveness (whether it works in real-world settings). Third, it supports research that tests culturally informed treatment approaches and recovery interventions, recognizing that treatment and recovery strategies may need to align with community context, values, and lived experience to be meaningful and successful. Fourth, when there is already solid evidence that an intervention works, the FOA encourages dissemination and implementation research that identifies and tests practical strategies to overcome real barriers to adoption, integration into routine practice, scale-up, and long-term sustainability.
A major theme throughout the announcement is that interventions should not be designed as one-off demonstrations that disappear when the study ends. Instead, projects are expected to consider sustainability within the communities where the research is conducted, and to be designed with enough flexibility that they can be responsibly adapted, disseminated, and scaled to other Native communities when culturally appropriate. The FOA frames this as building on community knowledge and community resources, rather than importing solutions that may not fit local priorities or systems.
This is an R01 grant mechanism, and clinical trials are optional, meaning applicants may propose clinical trials if they are appropriate for the intervention being tested, but a trial is not required. The program sits within NIH and is associated with multiple CFDA numbers (including 93.113, 93.121, 93.242, 93.273, 93.279, 93.286, 93.307, 93.361, 93.399, 93.846, 93.855, and 93.879), reflecting that multiple NIH institutes and centers may have interests aligned with Native health intervention research.
Eligibility is broad and includes many U.S.-based organization types that could credibly conduct or partner on this work. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public housing authorities and Indian housing authorities; public and private institutions of higher education; federally recognized tribal governments; tribal organizations (including those other than federally recognized tribal governments); nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The FOA also explicitly references eligibility or relevance for community-anchored and minority-serving institutions and organizations, such as Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed, which typically means limited, well-justified elements of a project may involve foreign collaboration or activities if they are necessary and compliant with NIH policy.
Key administrative details included in the source information are that the opportunity is a discretionary grant program administered by NIH, was created on 2020-08-17, and listed an original closing date of 2023-09-07. The provided listing does not specify an award ceiling or the expected number of awards, suggesting applicants would need to consult the full FOA text and relevant NIH institute guidance for budgeting norms, project period expectations, and institute-specific priorities.
Overall, this opportunity is intended for teams that can combine strong scientific methods with meaningful community engagement to produce interventions that are evidence-based, culturally appropriate, and realistically maintainable in Native communities. It supports everything from foundational research that clarifies what drives a health problem in context, to rigorous testing of interventions, to the practical work of making proven interventions easier to adopt and sustain in real settings.Apply for PAR 20 238
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.242, 93.273, 93.279, 93.286, 93.307, 93.361, 93.399, 93.846, 93.855, 93.879.
- This funding opportunity was created on 2020-08-17.
- Applicants must submit their applications by 2023-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title and identifier of this NIH funding opportunity?
The funding opportunity is titled "Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)" and the FOA number is PAR-20-238.
What is the main purpose of this opportunity?
The purpose is to support research projects that improve health outcomes in Native American populations by developing, adapting, testing, and helping communities sustain interventions that reduce illness and prevent early death.
Which populations are the focus of the research?
The focus is on Native American populations, including Alaska Natives and American Indians.
What kinds of health challenges is the FOA trying to address?
The FOA is designed around major acute and chronic disease inequities experienced by many Native communities, including inequities shaped by sociopolitical, historical, environmental, and structural stressors.
Does the FOA also emphasize community strengths and resilience?
Yes. The FOA highlights that Native communities have strengths, resources, and resilience that should guide effective, culturally grounded solutions.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 grant mechanism.
Are clinical trials required under this FOA?
No. Clinical trials are optional. Applicants may propose a clinical trial if it fits the intervention being tested, but a clinical trial is not required.
What types of research projects are supported along the intervention continuum?
The FOA supports multiple intervention-related project types, depending on what is already known in a health area, including etiologic research, intervention development and testing, culturally informed treatment and recovery approaches, and dissemination and implementation research when evidence is already strong.
When does the FOA encourage etiologic research?
Etiologic research is encouraged when there is a clear and significant gap in knowledge and filling that gap would directly inform how an intervention should be developed or adapted.
Does the FOA support developing, tailoring, or testing prevention and health promotion interventions?
Yes. The FOA funds studies that develop, tailor, or test health promotion and disease prevention interventions, including projects assessing efficacy and effectiveness.
What is the difference between efficacy and effectiveness in the context of this FOA?
Efficacy refers to whether an intervention works under more controlled conditions, while effectiveness refers to whether it works in real-world settings.
Does the FOA support treatment and recovery interventions?
Yes. It supports research that tests culturally informed treatment approaches and recovery interventions that align with community context, values, and lived experience.
What does the FOA mean by dissemination and implementation research?
When there is already solid evidence that an intervention works, the FOA encourages research to identify and test practical strategies to overcome barriers to adoption, integration into routine practice, scale-up, and long-term sustainability.
Is sustainability expected to be part of the project design?
Yes. A major theme is that interventions should not be one-off demonstrations that disappear when the study ends. Projects are expected to consider sustainability within the communities where the research is conducted.
Does the FOA support adapting or scaling interventions to other Native communities?
Yes, with important conditions. Projects should be designed with enough flexibility to be responsibly adapted, disseminated, and scaled to other Native communities when culturally appropriate.
How does the FOA frame community engagement and solution design?
The FOA emphasizes building on community knowledge and community resources, rather than importing solutions that may not fit local priorities or systems.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types, including state, county, and local governments; special district governments; independent school districts; public housing authorities and Indian housing authorities; public and private institutions of higher education; federally recognized tribal governments; tribal organizations (including those other than federally recognized tribal governments); nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and other eligible entities.
Are federally recognized tribal governments eligible applicants?
Yes. Federally recognized tribal governments are listed as eligible applicants.
Are tribal organizations that are not federally recognized eligible?
Yes. The FOA includes tribal organizations, including those other than federally recognized tribal governments, among eligible applicants.
Are nonprofits eligible, and do they need 501(c)(3) status?
Nonprofits are eligible whether or not they have 501(c)(3) status.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also listed as eligible.
Are colleges and universities eligible to apply?
Yes. Both public and private institutions of higher education are eligible.
Does the FOA explicitly reference minority-serving and community-anchored institutions?
Yes. The FOA explicitly references eligibility or relevance for Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and faith-based or community-based organizations, among others.
Are U.S. territories or possessions included as eligible entities?
Yes. U.S. territories or possessions are explicitly referenced.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Can a U.S. organization apply if the work is primarily conducted through a non-U.S. component?
No. Non-U.S. components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed at all?
Yes. Foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, which typically means limited, well-justified elements may involve foreign collaboration or activities if necessary and compliant with NIH policy.
Which agency administers this opportunity?
This is a discretionary grant program administered by the National Institutes of Health (NIH).
Do multiple NIH institutes and centers participate in this program?
The listing indicates the program is associated with multiple CFDA numbers, suggesting multiple NIH institutes and centers may have aligned interests in Native health intervention research.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers, including 93.113, 93.121, 93.242, 93.273, 93.279, 93.286, 93.307, 93.361, 93.399, 93.846, 93.855, and 93.879.
When was this opportunity created?
The provided information states the opportunity was created on 2020-08-17.
What was the original closing date listed in the provided information?
The provided listing states an original closing date of 2023-09-07.
Does the provided listing state an award ceiling?
No. The provided listing does not specify an award ceiling.
Does the provided listing state the expected number of awards?
No. The provided listing does not specify the expected number of awards.
What should applicants do about budgeting norms or project period expectations if they are not in the listing?
The provided information suggests applicants would need to consult the full FOA text and relevant NIH institute guidance for budgeting norms, project period expectations, and institute-specific priorities.
What kind of team or approach does this opportunity seem intended for?
It is intended for teams that combine strong scientific methods with meaningful community engagement to produce interventions that are evidence-based, culturally appropriate, and realistically maintainable in Native communities.
Does this FOA support both foundational research and real-world implementation work?
Yes. It supports work ranging from foundational research that clarifies drivers of a health problem in context, to rigorous testing of interventions, to practical efforts that make proven interventions easier to adopt and sustain in real settings.
Browse more opportunities from the same category: Education, Environment, Health
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