Opportunity Information: Apply for RFA DK 26 306

This funding opportunity supports research focused on improving stem cell-derived islet cell products for use in cell replacement therapy for type 1 diabetes. The goal is to engineer these cells to have enhanced durability, resilience, and function, using their reproducible and controlled manufacturing processes—advantages over traditional cadaveric islets. It encourages exploration of biological targets and pathways that can be leveraged for cell engineering, as well as preclinical testing of these strategies.

The initiative is part of the Special Diabetes Program, which backs innovative research aimed at better prevention, treatment, and potential cures for type 1 diabetes and its complications.

Eligibility is limited to U.S.-based institutions. Foreign organizations and subawards to international collaborators are not allowed. While unfunded international collaborations or foreign consulting may be permitted, no funds can be directed to foreign institutions or subcontractors under this specific grant.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Engineering Improved Stem Cell-Derived Islet Cells for Replacement Therapies (R01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
  • This funding opportunity was created on 2025-12-03.
  • Applicants must submit their applications by 2026-03-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • The number of recipients for this funding is limited to 6 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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